Wound Care Treatment Research Involving Unlikely Sources

Smartware for wound care is one of the major advancements of medical technology, and has made treating wounds significantly more efficient thanks to effective wound care documentation. Helping further are the technological advancements being made in topical treatments and dressings that have the potential to bring about remarkable results.

DRGN-1 from the Komodo Dragon for Antimicrobial Activity

Wound Care TreatmentCan the Komodo dragon help in wound care? Well, it’s certainly working for mice. Researchers have discovered that an antimicrobial cationic peptide in the Komodo dragon’s blood can give rise to a treatment that works to promote wound healing.

A study under the funding of the US Defense Threat Reduction Agency has researched this and developed the DRGN-1 synthetic peptide that is based on a peptide derived from histone H1 from the Komodo dragon.

DRGN-1 was tested for its antibiofilm and antimicrobial activity against two bacterial strains producing biofilm. During the test, DRGN-1 was discovered to permeate the bacterial membranes and display possible antibiofilm and antimicrobial activity while promoting keratinocyte migration.

DRGN-1 was found to enhance wound healing significantly in mixed as well as uninfected biofilm-infected mice wounds. This has led to researchers considering DRGN-1 a candidate worth spending further development on, as a topical treatment solution for wounds.

Creating Dressings at the Point of Care with Nanofibers

In a completely different kind of wound care research, nanofiber production is being considered for producing sterile bandages. With the risk of cross-contamination and infection looming large, it takes a good deal of care and consideration right from the packaging of bandages at the manufacturing facility, through the testing and transportation stages, to the point of use. This ensures the dressings are sterile right from the time of manufacture to when they are used.

This revolutionary nanofiber research, though, aims at doing away with the time and space gap between the point of manufacture and point of use. The researchers have developed a portable nanofiber manufacturing method that can be used at the wound care facility for applying the sterile bandages to the wound.

The Wyss Institute for Biologically Inspired Engineering’s Disease Biophysics Group at Harvard has developed a handheld device for producing nanofibers quickly. The real breakthrough is the ability of the device to enable the user to precisely control the fiber orientation, which helps create dressings that fit perfectly with the wound contours and perform their task effectively. The right fiber alignment is essential to ensure the material’s mechanical properties are optimized, and that they play their part in the healing process. It’s therefore important that one can regulate the deposition and alignment of the fiber.

Pull Spinning

This fabrication technique that was developed by these researchers, and can be used at the point of care, is called pull spinning. This involves a bristle rotating at high speed that dips into a protein or polymer reservoir to pull a droplet from the solution into a jet. The fiber, which moves about spirally on the bristle, then solidifies and detaches from the bristle as it moves towards a collector. Pull spinning was also found to work with different proteins and polymers.

There is great scope for this technique, and when it does launch commercially it could be a massive shot in the arm for advanced wound care since appropriate dressings can be created at the point of care.

With high tech and customized smartware for wound care, and the aforementioned technologies being developed, wound treatments bring about better outcomes faster.