Research Identifies Human Gene Product to Regulate Wound Healing

Human Gene Product Wound HealingPoorly managed wounds can get infected and lead to other complications. Better wound healing requires proper wound assessment, which is now easy with wound-specific EMR. It helps in better documentation and treatment of the wound and makes the job of physicians and nurses a lot easier and more efficient. With many ongoing studies and researches, it is clear that medical science is examining various ways to minimize scarring and encourage wound healing.

A recent study from researchers at Ohio State University has identified the human gene which helps to regulate wound healing and control scarring. Earlier, the team had identified MG53, a novel tripartite motif family protein as an essential component of the cell membrane repair machinery. The recent study reports the functional role of MG53 in the modulation of wound healing and scarring.

Therapeutic Benefits of MG53

It has been found that the protein travels throughout the bloodstream and helps the body fix injuries to the skin, heart, and other organs without causing scars.

This protein could help to reduce recovery time after surgery and the spread of infections by:

  • Healing open wounds and
  • Controlling scarring in people recovering from severe injuries and damage to internal organs

Research done using genetically engineered mice without the gene shows that the mice had difficulty recovering from injury, because of their compromised repair capacity and their heart would not function well under stress conditions.

MG53 also interferes with another protein called TGF Beta, a type of “cytokine” protein that also heals wounds, but the healing process happens so quickly that it causes scars. Those with more TGF Beta in their bloodstream than MG53 are more prone to having scars.

The researchers aim at developing a therapy that will inhibit TGF Beta and promote MG53. Medical professionals can use this therapy to promote quick, scarless healing.

Improve Wound Care with Better Documentation

Quality wound care requires constant observation, documentation and effective management. Detailed assessment is crucial mainly for chronic wounds. Wound care EMR has separate modules for physicians and nurses, where patient data and observations can be entered at each stage of the treatment. Advanced wound management software allows uploading photographs to show treatment progress. It is ideal for wound clinics to choose an EMR app with HL7 compliance, real time reporting, and 3D models.