New SIS Product Found to Manage Diabetic Foot Ulcer More Effectively

A recent study found that a new three-layer porcine small intestine submucosa (SIS) wound-care product manages diabetic foot ulcers (DFUs) better than standard care. Foot ulcers treated with this product showed more rapid healing and a greater possibility for complete wound closure compared to standard care. Diabetic foot ulcers are a leading cause of lower limb amputations and one of the most common reasons for hospitalization among diabetes patients. These types of wounds often fail to heal owing to poor blood glucose control, necrotic tissue, chronic inflammation, infection and inadequate perfusion. The new product can make a big difference in treating such hard-to-heal wounds and ensure better wound care.

For this study, Oasis Ultra Tri-Layer Matrix product from Smith & Nephew was used. DFU patients from 11 centers participated in this prospective randomized controlled trial while qualified subjects were randomized (1:1) to either SIS or standard care. The patients were treated for 12 weeks and a follow-up was performed for another 4 weeks after the completion of the study. The significant study results are given below.

  • Foot ulcers managed with SIS had a significant proportion closed by 12 weeks compared to that of the Control Group (54% V/s 32%). During all visits, this proportion was numerically higher.
  • Time taken for achieving wound closure was 2 weeks earlier for SIS group than for the group treated with standard care.
  • During each weekly visit, median reduction in the ulcer area was significantly greater for SIS.

On the whole, it was found that DFUs were over twice as likely to close when treated with SIS compared to standard care. The review of reported adverse events found no safety concerns.

Though the new product has been found to be very effective for DFU, a thorough evaluation of the patient is required before choosing this as a treatment. For any treatment intervention, it is necessary to consider the patient’s medical status, the status of the wound healing phase and all treatment used to achieve the expected outcome. The treatment intervention must be compatible with the patient and the wound. This requires a collaboration of wound care team members including nurses, physicians, and pharmacists. A standardized documentation system is very important in such a situation so that the team members can communicate with each other in an effective manner.

Even though electronic medical records (EMR) can ensure faster access to the required information, an EMR specialized for wound care is more effective in determining the correct treatment. A general EMR system is comprised of general templates and the wound care team will have to search through all of them to find the information they want, which is time-consuming. On the other hand, wound EMR that has wound-specific templates will be more beneficial because it will make it easier for the team to access the required data and choose an effective treatment. You can also create customized outcome reports quickly with wound EMR.