Mature B lymphocytes Speed up the Healing of Diabetic Ulcers and Other Skin Injuries

Diabetic UlcersA research team from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) has found a potential solution that can speed up the healing of chronic wounds. The researchers reported that the application of mature B lymphocytes greatly improved the healing of wounds in both healthy and diabetic skin. The treatment improved the quality of regenerated tissue and reduced scarring as well. Diabetic patients are more likely to develop chronic wounds, particularly foot ulcers, due to diabetic neuropathy and vascular disease. Such chronic wounds are difficult to heal. Generally, healthy wound healing has four phases which are: blood clotting to stop bleeding; inflammation to remove dead and damaged cells; proliferation of new tissue; and the remodeling of tissues to be stronger and better organized. Chronic wounds, they get stuck in an inflammatory phase with a low-oxygen microenvironment and the persistent presence of enzymes, breaking down the tissue proteins.

However, the series of experiments conducted by the VIC study team by separating mature B cells from the spleens of diabetic and non-diabetic mice showed that a single application of concentrated mature B cells helped in healing the wound faster, improving the quality of tissue repair in both animal models, reducing the size and improved the healing of chronic skin ulcers in the diabetic mice. They also isolated the B cells from older obese diabetic mice and applied to acute wounds in similarly aged, obese diabetic mice, and the healing effect was the same. In fact, these groups of animals were equivalent to 55 to 60 year old morbidly obese patients with uncontrolled diabetes. The type of mature B cells used in the study had a limited life span, and once applied on a wound; they remained active at the site for up to 14 days, making them easier to control than other types of cells used in therapies.

Just as the Mature B cells accelerate the healing of diabetic ulcers and other skin injuries, utilization of an advanced wound management software helps healthcare providers to speed up their documentation process.